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Toxic epidermal necrolysis after first dose of Pfizer-BioNTech (BNT162b2) vaccination with pharmacogenomic testing.

Siripipattanamongkol, Nunthana; Rattanasak, Sirawich; Taiyaitieng, Chanya; Inthajak, Yanapha; Kuawatcharawong, Nitchamon; Sukasem, Chonlaphat; Tempark, Therdpong.

Pediatr Dermatol ; 39(4): 601-605, 2022 Jul.

Article in English | MEDLINE | ID: covidwho-2001730

ABSTRACT

Toxic epidermal necrolysis (TEN) is a rare and acute life-threatening condition and one of the severe cutaneous adverse drug reactions. There are limited data on TEN from the COVID-19 vaccine regarding its pathogenesis, treatment, and prognosis, particularly in children. We report a case of COVID-19 vaccine-induced TEN and the patient's human leukocyte antigen pharmacogenomic profile.

Subject(s)

COVID-19 Vaccines , COVID-19 , Stevens-Johnson Syndrome , BNT162 Vaccine , COVID-19/prevention & control , COVID-19 Vaccines/adverse effects , Child , Humans , Pharmacogenomic Testing , Stevens-Johnson Syndrome/etiology , Stevens-Johnson Syndrome/genetics , Vaccination/adverse effects

ABSTRACT

Subject(s)

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